期刊
ANALYSIS OF CARDIAC DEVELOPMENT: FROM EMBRYO TO OLD AGE
卷 1188, 期 -, 页码 25-31出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05079.x
关键词
stem cells; differentiation; precursor cells; morphogenesis; mechanical loading; matrix stiffness; extra cellular matrix
资金
- Joseph Drown Foundation
- Herbert Berman Fund
Stem cell differentiation, both in vivo and in vitro, is regulated by a variety of signals. These signals can be of biochemical origin, such as those from growth factors and cytokines, or from different mechanical loads, such as fluid shear stress and matrix elasticity. The mechanisms by which the mechanical loads affect precursor cell differentiation are not entirely understood, but their role in regenerative medicine and cell therapy could be of vast importance. This paper reviews the role of mechanical loads on the differentiation of precursor cells.
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