期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 54, 期 3, 页码 354-358出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.354
关键词
Kobresia nepalensis; nepalensinol; stilbene; topoisomerase; inhibitor
Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 mu M.
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