期刊
JOURNAL OF SHOULDER AND ELBOW SURGERY
卷 15, 期 2, 页码 224-231出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jse.2005.06.007
关键词
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Large rotator cuff tears represent a challenging problem. The purpose of our study was to evaluate the small intestinal submucoso (SIS) extrocellular matrix in reconstruction of such defects in on animal model. Forty rats were equally divided into an SIS group (reconstruction of a large supraspinotus tendon defect by use of the SIS) and a defect group (no repair). The operative and contralateral normal shoulders underwent histologic evaluation and biomechanical testing at 6 and 16 weeks. Neovascularization and fibroblastic ingrowth were present in SIS-regenerated tendons, which had an ultimate force to failure that was 78% of normal at 16 weeks. This was higher than in the defect group, which demonstrated on ultimate force to failure that was 34% of normal (P =.008). The ultimate force to failure of the SIS-regenerated tendons approached that of the normal tendon at 16 weeks. The SIS extracellular matrix served as a scaffold promoting host tissue ingrowth and appears promising in the management of large rotator cuff defects in a rot model. However, human beings sustain tears at the bone-tendon interface and demonstrate decreased healing potential relative to rats. Therefore, the findings of this preliminary study should not be extrapolated to human beings without further investigation.
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