期刊
FOODS FOR HEALTH IN THE 21ST CENTURY: A ROAD MAP FOR THE FUTURE
卷 1190, 期 -, 页码 58-69出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05274.x
关键词
IgE; food allergy; food matrix; polyphenol; walnut; Juglans; mouse; antibodies; allergy; sensitization
资金
- NIH [K23 AI01604]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K23AI001604] Funding Source: NIH RePORTER
English walnuts are implicated in severe, IgE-mediated food allergy in humans. We sought to determine if polyphenolic compounds extracted from the edible nut could promote IgE production to a coadministered allergen. BALB/c mice were sensitized to ovalbumin (OVA) with or without alum (AL) or polyphenolic-enriched extract via intraperitoneal injection. Serum was analyzed for total IgE and OVA-specific IgE, IgG(1), and IgG(2a/2b). Coadministration of walnut polyphenolic-enriched extract with antigen and AL increased serum concentrations of antigen-specific IgE and IgG(1) When AL was excluded from the injections, polyphenolic extract tended to enhance OVA-specific IgE and IgG(1) over levels induced by OVA alone, but the increase did not reach significance. Serum IgG(2a/2b) levels were similar between mice receiving OVA/AL and OVA/AL with polyphenolics. Thus, walnut polyphenolic extract enhanced the Th2-skewing effect of an aluminum hydroxide adjuvant. This indicates that walnut polyphenolic compounds may play a role in allergic sensitization of genetically predisposed individuals.
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