期刊
WOMEN'S HEALTH AND DISEASE
卷 1205, 期 -, 页码 106-117出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05674.x
关键词
acquired thrombophilia; inherited thrombophilia; adverse pregnancy outcome; deep venous thrombosis
Both acquired and inherited thrombophilias are associated with an increased risk of pregnancy-related venous thromboembolism (VTE) as well as with adverse pregnancy outcome. However, the extension of attributable risk for each thrombophilia and outcome is still a question of debate. Thrombophilias have been investigated in connection with VTE and pregnancy complications such as: recurrent and nonrecurrent early pregnancy loss, late fetal death, placental abruption, fetal growth restriction, and preeclampsia. This review discusses the evidence of association between thrombophilias and pregnancy outcome together with issues as to clinical management and preventive strategies.
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