期刊
MAGNETIC RESONANCE IN MEDICINE
卷 55, 期 3, 页码 676-680出版社
WILEY
DOI: 10.1002/mrm.20788
关键词
double-quantum filter; PRESS; GSH; human brain; MRS
资金
- NIBIB NIH HHS [R01EB002009] Funding Source: Medline
In this work, a new double quantum filter for glutathione (GSH) editing is introduced, combined with the point-resolved spectroscopy localization sequence (PRESS), and demonstrated in vivo. Compared to the conventional double quantum coherence filter, the new filter has two major advantages. First, it eliminates the need for calibration scans for optimizing the signal yield, making it more efficient and convenient for routine use. Second, it removes the influence of water saturation pulses on the GSH yield, further improving its accuracy. With this method, GSH concentrations in the left and right parietal lobes of five healthy volunteers were determined to be 0.91 +/- 0.16 mM and 0.89 +/- 0.16 mM, respectively, in agreement with previous studies. Magn Reson Med 55: 676-680, 2006. (c) 2006 Wiley-Liss, Inc.
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