期刊
NEURONS AND NETWORKS IN THE SPINAL CORD
卷 1198, 期 -, 页码 252-259出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05499.x
关键词
spinal cord injury; intermittent hypoxia; plasticity
资金
- NIH [HL69064, HL80209, NS05777, T32 HL07654, F31 HL092785]
- Francis Family Foundation
- Craig H. Neilsen Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL069064, R01HL080209, R01HL069064, F31HL092785, T32HL007654] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008692] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS057778] Funding Source: NIH RePORTER
Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain-derived neurotrophic factor, activation of its high-affinity receptor, tropomyosin-related kinase B, and extracellular-related kinase mitogen-activated protein kinase signaling in or near phrenic motor neurons. Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury. Because repetitive AIH induces phenotypic plasticity in respiratory motor neurons, it may restore respiratory motor function in patients with incomplete spinal injury.
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