期刊
EPIGENETICS AND NEUROPSYCHIATRIC DISEASES: MECHANISMS MEDIATING NATURE AND NURTURE
卷 1204, 期 S1, 页码 E8-E13出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05644.x
关键词
epigenetics; reproduction; genetics; paternal age; schizophrenia
资金
- NATIONAL CANCER INSTITUTE [K07CA131094] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K08MH085807] Funding Source: NIH RePORTER
- NCI NIH HHS [K07 CA131094] Funding Source: Medline
- NHGRI NIH HHS [L30 HG004809] Funding Source: Medline
- NIMH NIH HHS [K08 MH085807] Funding Source: Medline
Epigenetics holds promise to explain some puzzles concerning the risk and course of psychiatric disorders. Epigenetic information is essential as a set of operating instructions for the genome, which is heritable with DNA. The epigenetic regulation of gene expression can plausibly be influenced by the environment of one's ancestors, prenatal exposures, and by early life events. Some epigenetic mechanisms may alter neurophysiology throughout life by programming gene expression, perhaps in anticipation of certain life experiences. These epigenetic signals are only meta-stable and may be perturbed by stochastic events, errors, or by environmental toxins. This introduction considers the possibility that epigenetic change that may occur as paternal age advances or during fetal adversity may be causally related to the susceptibility for schizophrenia.
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