期刊
SYNTHESIS-STUTTGART
卷 -, 期 5, 页码 753-755出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-926342
关键词
cross-coupling; synthesis; FTY720; inuounosuppressants; alkynes
The concise and practical synthesis of the biologically important FTY720 was achieved employing the palladium-catalyzed Sonogashira coupling reaction as a key step. The commercial tris(hydroxymethyl)aminomethane was converted to alkyne 2 via a three-step synthesis. The coupling reactions of alkyne 2 with aryl iodide 3, followed by subsequent hydrogenation of the internal alkyne and removal of the protecting groups provided FTY720 in high overall yield.
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