期刊
ORGANIC LETTERS
卷 8, 期 5, 页码 899-902出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol052994+
关键词
-
资金
- NCI NIH HHS [CA-99957] Funding Source: Medline
- NCRR NIH HHS [RR-16480] Funding Source: Medline
Privileged medicinal scaffolds based on the structures of 2-amino-3,5-dicyano-6-sulfanylpyridines and the corresponding 1,4-dihydropyridines have been prepared via a single-step, three-component reaction of structurally diverse aldehydes with various thiols and malononitrile. Mechanistic studies revealed that 1,4-dyhidropyridines undergo oxidation by the intermediate Knoevenagel adducts rather than by air oxygen. Although the latter process undermines the yields of pyridines, it results in the formation of substituted enaminonitriles, promising antiinflammatory agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据