Triphenylphosphine as a ligand for room-temperature Ni(O)-catalyzed cross-coupling reactions of aryl chlorides with arylboronic acids

Room-temperature Ni(0)-catalyzed cross-coupling reactions of deactivated aryl chlorides with arylboronic acids with inexpensive tripherrylphosphine (PPh3) as a supporting ligand have been accomplished in good to excellent yields. Airstable Ni(PPh3)(2)Cl-2 has also been established as catalyst precursor, and highly active nickel catalysts were obtained when the reduction of Ni(PPh3)(2)Cl-2 with n-BuLi was carried out in the presence of an aryl chloride.