期刊
FEBS LETTERS
卷 580, 期 6, 页码 1531-1535出版社
WILEY
DOI: 10.1016/j.febslet.2006.02.014
关键词
14-3-3; binding motif; mode III; cancer signaling; C-terminal; SWTY; phosphorylation; binding assay; fluorescence anisotropy
资金
- NIGMS NIH HHS [GM70959] Funding Source: Medline
Amino and carboxyl termini are unique positions in a polypeptide. They tend to be exposed in folded three dimensional structures. Diversity and functional significance of C-terminal sequences have been appreciated from studies of PDZ and PEX domains. Signaling 14-3-3 protein signaling by recognizing phosphorylated peptides plays a critical role in a variety of biological processes, including oncogenesis. The preferential binding of 14-3-3 to phosphorylated C-terminal sequences, mode III, provides a means of regulated binding and considerably expands the substrate repertoire of 14-3-3 interaction partners. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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