期刊
MECHANISMS OF EXOCYTOSIS
卷 1152, 期 -, 页码 93-99出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03995.x
关键词
SNAP-25; schizophrenia; epilepsy; ADHD; calcium channels
资金
- European Union [GP04196]
- Cariplo [2006.0779/10.9251]
- Compagnia di S.Paolo [Prog. 2005.1964]
- National Institutes of Health [MH48989]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH048989] Funding Source: NIH RePORTER
- Fondazione Telethon Funding Source: Custom
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.
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