期刊
FEBS LETTERS
卷 580, 期 6, 页码 1571-1575出版社
WILEY
DOI: 10.1016/j.febslet.2006.01.084
关键词
astrocytes; DNA arrays; p8; oxidative stress; heme oxygenase 1; p38 MAPK
Here we studied the mechanism of cell sensitization to oxidative stress by analyzing the gene expression profile of serum-deprived astrocytes. Exposure to serum-free medium (i) sensitized astrocytes to oxidative stress, (ii) reduced the expression of several genes involved in protection against oxidative stress, including heme oxygenase 1, and (iii) changed the expression of several genes involved in the control of cell survival, including the stress-regulated protein p8. Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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