期刊
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE
卷 1170, 期 -, 页码 184-189出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.03895.x
关键词
chemosensation; trigeminal neuron; somatosensation; chemical irritant; TRP channel
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007048] Funding Source: NIH RePORTER
- NIGMS NIH HHS [T32 GM007048-35, T32 GM007048] Funding Source: Medline
Three sensory systems, olfaction, taste, and somatosensation, are dedicated to the detection of chemicals in the environment. Trigeminal somatosensory neurons enable us to detect a wide range of environmental stimuli, including pressure, temperature, and chemical irritants, within the oral and nasal mucosa. Natural plant-derived irritants have served as powerful pharmacological tools for identifying receptors underlying somatosensation. This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively. In addition to TRP channels, members of the two-pore potassium channel family have also been implicated in trigeminal chemosensation. KCNK18 was recently identified as a target for hydroxy-alpha-sanshool, the tingling and numbing compound produced in Schezuan peppers and other members of the Xan-thoxylum genus. The role of these channels in trigeminal thermosensation and pain will be discussed.
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