期刊
NEUROSCIENCE LETTERS
卷 395, 期 2, 页码 93-97出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.10.057
关键词
memantine; depression; forced swimming test; PKA; MAPK/ERK; CaMKII
This study investigated the cellular signaling pathways involved in the acute antidepressant-like action of memantine in the forced swimming test (FST) in mice. The immobility time in the FST was reduced by memantine (3-10 mg/kg, i.p.). The anti-immobility effect of memantine (3 mg/kg, i.p.) was prevented by pretreatment with H-89 (1 mu g/site, i.c.v., an inhibitor of PKA), PD098059 (5 mu g/site, i.c.v., an inhibitor of MAPK/ERK), KN-62 (mu g/site, i.c.v., an inhibitor of CaMKII), but not with chelerythrine (1 mu g/site, i.c.v., an inhibitor of PKC). Taken together, these results firstly demonstrate that the acute antidepressant-like effect of memantine seems to be dependent on the cellular signaling modulated by PKA, CaMKII and MAPK/ERK, but not by PKC. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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