期刊
CONTEMPORARY CHALLENGES IN AUTOIMMUNITY
卷 1173, 期 -, 页码 83-91出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04653.x
关键词
acute rheumatic fever; autoantigen; Australian indigenous communities; human heart cDNA expression library; Group A streptococcus
资金
- Channel 7 Childrens' Research Foundation of South Australia
- Cooperative Research Centre for Aboriginal and Tropical Health
- NHMRC
- Alexander von Humboldt Fellowship
- National Heart Foundation of Australia
- Ian Potter Foundation, Australia
Acute rheumatic fever (ARF) is an autoimmune sequela of group A streptococcal infection mostly affecting school-aged children. Recurrent episodes of ARF can result in the development of rheumatic heart disease (RHD). One in 40 indigenous Australians in the Northern Territory is affected by RHD. This disease mostly impacts young people; 45% of those who require heart valve surgery in Australia due to RHD are younger than 25 years old. ARF is characterized by autoimmune attack of the heart; therefore, the presence of the autoantibodies involved could potentially be used to diagnose ARE To this end, a human heart cDNA library was screened with serum from a patient with ARF, and 12 autoreactive human heart antigens were identified. They include five different IgG heavy chains and a range of tissue-specific cell-signaling proteins, species of which have been implicated in other autoimmune diseases. Preliminary ELISA results show that ARE patients have significantly higher levels of antibodies recognizing the cardiac autoantigens than controls. These antigens are promising candidates for the development of a serological assay for the diagnosis of ARE The nature of the proteins identified has exciting implications for future research into the pathogenesis of ARF.
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