期刊
NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS
卷 1171, 期 -, 页码 176-182出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04727.x
关键词
apoptosis; Bcl-2; 4-hydroxynonenal; c-Jun N-terminal kinase; piceatannol
资金
- Korea Science and Engineering Foundation, Ministry of Science and Technology, Korea [R01-2007-000-11957-0, 2005-00407]
Alzheimer's disease (AD) is an age-related neurodegenerative disorder in which apoptosis plays a potentially important role. 4-Hydroxynonenal (HNE) is a major lipid peroxidation product produced by oxidative stress, and its level is elevated in the AD brain. In the present study, piceatannol (but not resveratrol) at the concentration of 20 mu mol/L inhibited HNE-induced PC12 cell death. Treatment with HNE induced nuclear condensation in PC12 cells, and this was attenuated by piceatannol treatment. HNE induced poly(ADP-ribose) polymerase cleavage and decreased Bcl-2 expression, with both of these effects being attenuated by piceatannol. Piceatannol also inhibited the phosphorylation of c-Jun N-terminal kinase, which is a key regulator of HNE-induced PC12 cell death. These results indicate that piceatannol has therapeutic potential in the prevention of AD.
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