期刊
STEROID ENZYMES AND CANCER
卷 1155, 期 -, 页码 309-315出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03678.x
关键词
Parkinson's disease (PD); nitric oxide (NO); corpus striatum; substantia nigra pars compacta (SNc); 6-hydroxydopamine (6-OHDA); dopamine (DA)
资金
- Ateneo di Palermo research funding [ORPA068JJ5]
The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease (PD) in rats. The effect of pharmacological manipulation of the NO system was evaluated on striatal dopamine (DA) level decrease produced by the toxin. 7-nitroindazole (7-NI, 50 mg/kg i.p.; n = 5) pretreatment significantly restored the striatal DA contents. Conversely, 40 mg/kg i.p. of molsidomine (MOL, it = 5), an NO donor, significantly worsened the neurodegeneration (n = 5) and completely counteracted the neuroprotective effect of 7-NI (n = 5). Thus, a crucial role for NO in 6-OHDA induced neurodegeneration is suggested together with a protective benefit for inhibitors of NOS in the treatment of PD.
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