期刊
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE
卷 1170, 期 -, 页码 224-238出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.03891.x
关键词
olfaction; glutamate; GABA; mitral cells; granule cells
资金
- Whitehall Foundation
- Howard University New faculty Research Program
- Biomedical Research Foundation of Northwest Louisiana
- United States Public Health Service [S06GM08016 (NIGMS/NIH), U54NS039407 (NINDS/NIH), DC008702, DC003195, DC06356, DC07123, DC009049, DC007876, RR020146]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR020146] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008016] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U54NS039407] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC008702, R03DC009049, R01DC003195, R01DC007123, R01DC007876, R03DC006356] Funding Source: NIH RePORTER
The main olfactory bulb (MOB) is the first site of synaptic processing in the central nervous system for odor information that is relayed from olfactory receptor neurons in the nasal cavity via the olfactory nerve (ON). Glutamate and ionotropic glutamate receptors (iGluRs) play a dominant role at ON synapses. Similarly, glutamate and iGluRs mediate dendrodendritic transmission between several populations of neurons within the MOB network. Neuroanatomical studies demonstrate that metabotropic glutamate receptors (mGluRs) are densely expressed through the MOB network, and they are particularly abundant at dendrodendritic synapses. Until recently, the physiological roles of mGluRs in the MOB were poorly understood. Over the past several years, mGluRs have been shown to play surprisingly powerful neuromodulatory roles at ON synapses and in dendrodendritic neurotransmission in the MOB. This chapter focuses on recent advances in our understanding of mGluR-mediated signaling components at dendrodendritic synapses.
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