期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 533, 期 1-3, 页码 195-206出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.12.061
关键词
nerve growth factor; nerve growth factor receptor; asthma; airway hyperreactivity; airway inflammation; neurogenic inflammation
Neurotrophins like nerve growth factor (NGF), originally described as nerve growth factors in neuronal development, have been implicated in many physiological processes in the last years. They are now regarded as important factors involved in the resolution of pathological conditions. NGF has profound effects oil inflammation, repair and remodeling of tissues. However, in the lung these beneficial effects call transact into disease promoting actions, e.g., in allergic inflammation or respiratory syncytial virus (RSV) infection. Overproduction of NGF then enhances inflammation, and promotes (neuronal) airway hyperreactivity and neurogenic inflammation. We hypothesize that NGF overexpression in certain vulnerable time windows during infancy could be a major risk factor for the development of asthma symptoms. (c) 2006 Elsevier B.V All rights reserved.
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