期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 104, 期 1-2, 页码 119-123出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.08.059
关键词
cinnamon; intestinal alpha-glycosidase; blood glucose; serum insulin; serum lipids
The anti-diabetic effect of Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) in a type 11 diabetic animal model (C57BIKsj db/db) was studied. Cinnamon extract was administered at different dosages (50, 100, 150 and 200mg/kg) for 6 weeks. It was found that blood glucose concentration is significantly decreased in a dose-dependent manner (P < 0.001) with the most in the 200 mg/kg group compared with the control. In addition, serum insulin levels and HDL-cholesterol levels were significantly higher (P < 0.01) and the concentration of triglyceride, total cholesterol and intestinal alpha-glycosidase activity were significantly lower after 6 weeks of the administration. These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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