期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 533, 期 1-3, 页码 302-307出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2005.12.045
关键词
allergic asthma; anti-IgE-antibody; allergic respiratory diseases; monoclonal antibody anti-IgE; omalizumab
IgE molecules play a crucial role in allergic respiratory diseases and may cause chronic airway inflammation in asthma through activation of effector cells via high-affinity (Fc epsilon RI) or low-affinity (Fc epsilon RII) IgE receptors. Since the discovery of IgE antibodies our understanding of the mechanisms of allergy has improved to such all extent that we can differentiate allergic/atopic from intrinsic respiratory diseases. Therapeutic anti-IgE antibodies, able to reduce free IgE levels and to block the binding of IgE to Fc epsilon RI without crosslinking IgE and triggering degranulation of IgE-sensitized cells have been developed. This non-anaphylactogenic anti-IgE monoclonal antibody (omalizumab) binds IgE at the same site as these antibodies bind Fc epsilon RI and Fc epsilon RII. Consequently, omalizumab inhibits IgE effector functions by blocking IgE binding to high-affinity receptors oil IgE effector cells and does not cause mast cell or basophil activation because it cannot bind to IgE oil cell surfaces where the Fc epsilon RI receptor already masks the anti-IgE epitope. Studies in patients with atopic asthma showed that omalizumab decreases serum IgE levels and allergen-induced bronchoconstriction during both the early and late-phase responses to inhaled allergen. In several clinical controlled trials omalizumab resulted effective in reducing asthma-related symptoms, decreasing corticosteroid use and improving quality of life of asthmatic patients. Recent studies show the benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled by optimal pharmacological therapy. The anti-IgE approach to asthma treatment has several advantages, including concomitant treatment of other IgE-mediated diseases such as allergic rhinitis, a favorable safety profile and a convenient dosing frequency. (c) 2006 Elsevier B.V. All rights reserved.
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