期刊
JOURNAL OF CONTROLLED RELEASE
卷 111, 期 1-2, 页码 128-134出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2005.11.006
关键词
microbubble; ultrasound radiation force; targeted; drug delivery; delivery vehicle; nanoparticle
资金
- NCI NIH HHS [R01 CA103828, R01 CA 103828] Funding Source: Medline
- NIAID NIH HHS [AI4792] Funding Source: Medline
A novel drug delivery vehicle that specifically targets using ultrasound radiation force (USPF) and biotin-avidin interactions is presented. Model vehicles consist of avidinated fluorescent nanobeads bound directly to the biotinylated lipid shells of preformed microbubbles. USRF was used to deflect the vehicle from the center of flow to a tube surface in order to facilitate receptor-ligand mediated adhesion. At wall shear stress levels commensurate with venous and arterial flow, USRF was used to direct the vehicles to a biotinylated tube surface. Subsequent high-pressure pulses fragmented the carrier, and molecular interactions induced deposition of the nanobeads on the wall. Targeting of nanobeads to the tube was molecularly specific and dependent on, in order of importance, vehicle concentration, wall shear stress, nanobead size, and insonation time. The observation that portions of the microbubble lipid monolayer shell remain attached to adherent nanobeads is important for future consideration of drug transport mechanisms. This versatile method of delivery is shown to enable targeted deposition of nanoparticles in shear flow and could be modified to carry therapeutic agents for controlled release in targeted delivery applications. (c) 2005 Elsevier B.V. All rights reserved.
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