期刊
STEROID ENZYMES AND CANCER
卷 1155, 期 -, 页码 15-24出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.03702.x
关键词
steroid metabolism; 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD); human disorders
Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17 beta-hydroxysteroid dehydrogenases (17 beta-HSD), act as carbonyl reductases and require cofactors for their catalytic activity There is a substantial amount of evidence that human 17 beta-HSDs are as well involved in the metabolic pathways of retinoids and fatty acid beyond that which has so far been anticipated. At present fourteen 17 beta-HSDs have been annotated and characterized, and more might follow. Many of 17 beta-HSDs have been shown to be involved in the pathogenesis of human disorders and are targets for therapeutic intervention. Strategies on deciphering the physiological role of the 17 beta-HSD and the genetic predisposition for associated diseases will be presented involving analyses of animal models.
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