期刊
YEAR IN IMMUNOLOGY 2008
卷 1143, 期 -, 页码 61-82出版社
WILEY-BLACKWELL
DOI: 10.1196/annals.1443.011
关键词
Siglec; human; mouse; leukocyte; ITIM; ITAM; sialic acid; lectin
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041472, R21AI041472, R56AI072265, R01AI072265] Funding Source: NIH RePORTER
- NIAID NIH HHS [R56 AI072265, R01 AI041472, R21 AI041472, AI72265, AI41472, R01 AI072265] Funding Source: Medline
Siglecs are cell-surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super-family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each human Siglec in numerical order, mentioning in turn its closest murine ortholog or paralog. Each section will describe its pattern of cellular expression, latest known immune functions, ligands, and signaling pathways, with the focus being predominantly on CD33-related Siglecs. Potential clinical and therapeutic implications of each Siglec will also be covered.
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