期刊
ADDICTION REVIEWS 2008
卷 1141, 期 -, 页码 257-269出版社
WILEY-BLACKWELL
DOI: 10.1196/annals.1441.027
关键词
substance abuse; vaccination; theory; cocaine; methamphetamine; nicotine; phencyclidine; morphine
资金
- Department of Veterans Affairs (VA) Merit Review Program
- VISN 16 Mental Illness Research, Education and Clinical Center (MIRECC)
- VA National Substance Use Disorders Quality Enhancement Research Initiative (QUERI)
- National Institute on Drug Abuse [K05 DA0454, P50-DA18197]
- NATIONAL INSTITUTE ON DRUG ABUSE [K05DA000454, P50DA018197, R01DA025223] Funding Source: NIH RePORTER
Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advanced stages of development. Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies in the bloodstream, thereby blocking entry and/or reducing the rate of entry of the drug into the central nervous system. The benefits of such antibodies on drug pharmacodynamics will be influenced by both the quantitative and the qualitative properties of the antibodies. The sum of these effects will determine the success of the clinical applications of antidrug vaccines in addiction medicine. This review will discuss these issues and present the current status of vaccine development for nicotine, cocaine, methamphetamine, phencyclidine, and morphine.
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