期刊
JOURNAL OF INFECTIOUS DISEASES
卷 193, 期 6, 页码 879-887出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/500471
关键词
-
资金
- NIAID NIH HHS [AI 48857] Funding Source: Medline
- NICHD NIH HHS [HD 37345] Funding Source: Medline
Background. Cytokines are important for inducing T cell maturation, proliferation, and survival. Despite the known dysregulation of cytokines in human immunodeficiency virus (HIV) infection, cytokine receptor expression is relatively unexplored. Methods. We examined maturation markers (naive, central memory, effector memory, and effector); the cytokine receptors interleukin (IL)-2R beta, common gamma (C gamma) chain, IL-7R alpha, IL-15R alpha; and proliferative responses of T cells in a cohort of HIV-infected pediatric patients (median age, 14.82 years) receiving antiretroviral therapy, arbitrarily designated as immunologic responders (group I) and nonresponders (group II) on the basis of a CD4(+) T cell count cutoff of 25%. Results. Patients had increased percentages of effector memory CD8(+) T cells, in comparison with those in healthy control subjects, with reduced expression of IL-7R alpha in the central memory and effector memory subsets and of the Cg chain in all maturation subsets of CD8(+) T cells. IL-7R alpha(+)CD8(+) T cell percentages were directly correlated with CD4(+) T cell percentages. In immunologic nonresponders, anti-CD3(+) or HIV Gag antigen-induced CD8(+) T cell proliferation was impaired, but proliferation in response to the homeostatic cytokines IL-2 and IL-15 was preserved. Conclusions. Cytokine receptor deficiencies may contribute to immune deficiency in HIV-infected patients, and gamma-chain-utilizing cytokines may play an important role in vivo in maintaining the memory subsets of T cells in patients with CD4(+) T cell deficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据