期刊
CELL CYCLE
卷 5, 期 6, 页码 582-584出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.6.2575
关键词
BID; ATM; DNA damage; cell cycle; S-phase; apoptosis; BH3-only; nucleus; mitochondria; phosphorylation
类别
DNA damage leads to the activation of ATM and ATR, which in turn either cause cell cycle arrest and DNA repair or apoptosis. We have demonstrated that DNA damage leads to ATM-mediated BID phosphorylation, and that this phosphorylation regulates a novel, pro-survival function of BID important for S phase arrest. Thus, BID, a member from the core apoptotic regulatory machinery (BCL-2 family) receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death.
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