期刊
MOLECULAR CELL
卷 21, 期 6, 页码 837-848出版社
CELL PRESS
DOI: 10.1016/j.molcel.2006.01.036
关键词
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资金
- NIEHS NIH HHS [R21 ES013511, ES013511] Funding Source: Medline
- NIGMS NIH HHS [R01 GM059150, GM070411, F31 GM070411, GM59150] Funding Source: Medline
- Wellcome Trust [073915, 043189] Funding Source: Medline
Condensins are essential protein complexes critical for mitotic chromosome organization. Little is known about the function of condensins during interphase, particularly in mammalian cells. Here we report the interphase-specific interaction between condensin I and the DNA nick-sensor poly(ADP-ribose) polymerase 1 (PARP-1). We show that the association between condensin 1, PARP-1, and the base excision repair (BER) factor XRCC1 increases dramatically upon single-strand break damage (SSB) induction. Damage-specific association of condensin I with the BER factors flap endonuclease 1 (FEN-1) and DNA polymerase delta/epsilon was also observed, suggesting that condensin I is recruited to interact with BER factors at damage sites. Consistent with this, DNA damage rapidly stimulates the chromatin association of PARP-11, condensin I, and XRCC1. Furthermore, depletion of condensin in vivo compromises SSB but not double-strand break (DSB) repair. Our results identify a SSB-specific response of condensin I through PARP-1 and demonstrate a role for condensin in SSB repair.
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