期刊
FEBS LETTERS
卷 580, 期 7, 页码 1716-1722出版社
WILEY
DOI: 10.1016/j.febslet.2006.02.021
关键词
transcription; cell cycle; CDK; FOXM1; p27; Cyclin A
The FOXM1 forkhead proteins, originally identified as M-phase phosphoproteins, are proliferation-associated transcriptional regulators involved in cell cycle progression, genetic stability and tumorigenesis. Here we demonstrate that Cyclin-dependent kinases regulate the transcriptional activity of FOXM1c. This is independent of an N-terminal negative regulatory domain and of the forkhead DNA binding domain. Instead we mapped the responsive sites in the transactivation domain. A combination of three phosphorylation sites mediates the Cyclin E and Cyclin A/CDK2 effects. Our findings provide evidence for a novel Cyclin E/CDK2 substrate that functions in cell cycle control. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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