期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 27, 期 6, 页码 441-446出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200500778
关键词
biomaterials; calcium phosphate; liposome; nanoparticles; polymer nanogel
We report novel organic-inorganic hybrid nanomaterials that consist of polymer hydrogel nanoparticles (nanogels) and calcium phosphate. Hybrid nanoparticles that measure ca. 40 nm are synthesized from a dilute solution of hydroxyapatite using nanogels as templates for calcium phosphate mineralization. These nanoparticles show a narrow size distribution and high colloidal stability. Nanogel-adsorbed liposomes act as templates for hierarchical hybrid nanostructures. These nanohybrids can potentially be used as biocompatible drug carriers with controlled-release properties.
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