期刊
TETRAHEDRON LETTERS
卷 47, 期 13, 页码 2257-2260出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.01.084
关键词
pyridopyridazines; pyrazinopyridazines; Aza-Wadsworth-Emmons cyclization; GABA(A) receptor ligands
Novel syntheses of 2,3,8-trisubstituted pyrido[2,3-d]pyridazines and 2,3,5-trisubstituted pyrazino[2,3-d]pyridazines are described. Two complementary routes to pyrido[2,3-d] pyridazines were developed, the first of which began by constructing the pyridine ring, and the second of which started by constructing the pyridazine ring. Pyrazino[2,3-d]pyridazines were prepared in a route employing an aza-Wadsworth-Emmons cyclization as the key step. The resulting compounds were found to be high affinity ligands for the GABA(A) receptor benzodiazepine binding site. (c) 2006 Elsevier Ltd. All rights reserved.
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