Studies directed towards the total synthesis of clavosolides: synthesis of an isomer of clavosolide A

The total synthesis of clavosolide A, employing a radical-mediated route to build its substituted tetrahydropyran unit, a Yamaguchi reaction to construct the diolide aglycon and the Schmidt method for the final glycosidation step, revealed that the reported structure is an isomer of the natural product. (c) 2006 Elsevier Ltd. All rights reserved.