期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 7, 页码 2848-2853出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo052677g
关键词
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A dynamic combinatorial library of thiocolchicine-podophyllotoxin derivatives based on the disulfide bond exchange reaction is described. The influence of a biological target on the composition of the reaction mixture has been demonstrated. Use of high-resolution ESI mass spectrometry to evaluate the composition of the mixture shows promise for the design of new large libraries. The biological evaluation demonstrates that formation of a divalent compound affords a new chemical entity whose biological activity is not merely the sum of the single ligands activities, thus reflecting a different interaction with the biological target.
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