期刊
NATURAL PRODUCT RESEARCH
卷 20, 期 4, 页码 327-334出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410500161205
关键词
Arbutus unedo; sterols; pentacyclic triterpenes; 7 beta-hydroxystigmast-4-en-3-one; pomolic acid 3-acetate; JB6 cell transformation assay; cyclooxygenase-2 inhibition assay
资金
- NCI NIH HHS [P01 CA48112] Funding Source: Medline
A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7 beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of I was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in the JB6 cell transformation assay was found for pomolic acid 3-acetate (4). All isolates obtained were evaluated in a cyclooxygenase-2 (COX-2) inhibition assay.
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