HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis:: The role of monocyte chemoattractant protein-1

Individuals with HIV-1 infection are at increased risk for cardiovascular events, and lipodystrophy is generally associated with proatheroizenic metabolic disturbances. We conducted a case-control study to assess the presence of sub-clinical atherosclerosis in HIV-1-infected patients with or without lipodystrophy (LD) and to evaluate the influence of monocyte chemoattractant protein-1 (MCP-1) on the development of both carotid atherosclerosis and LD. The study population consisted of 43 patients with LD and 86 patients without LD. We determined carotid intima-media thickness (IMT), MCP-1 concentrations in plasma, and MCP-1 genotype (presence or absence of the -2518G allele). HIV-1-infected patients with LD showed increased risk (OR = 3.71, 95% CI = 1.10-12.47, p = 0.03) for sub-clinical atherosclerosis. and MCP-1 plasma concentration was significantly correlated with IMT in these patients (Pearson - 0.31, p = 0.03). Furthermore. presence of LD was a determinant for MCP-1 plasma concentration (beta = 0.18, p = 0.05). In summary, HIV-1-infected patients with clinically manifest LD are at higher risk for atherosclerosis and our observations support the relationship between inflammation and atherosclerotic disease. (c) 2006 Elsevier Ltd. All rights reserved.