4.7 Article

Recurrence Patterns After Anatomic or Parenchyma-Sparing Liver Resection for Hepatocarcinoma in a Western Population of Cirrhotic Patients

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ANNALS OF SURGICAL ONCOLOGY
卷 25, 期 13, 页码 3974-3981

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SPRINGER
DOI: 10.1245/s10434-018-6730-0

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BackgroundThe optimal surgical strategy to lessen the risk of hepatocarcinoma (HCC) recurrence is debated. This study aimed to investigate the role of anatomic resection (AR) and parenchyma-sparing resection (PSR) in HCC recurrence patterns.MethodsThe study analyzed 384 cirrhotic patients with a first diagnosis of HCC. Of these patients, 142 underwent AR, and 242 underwent PSR. The two groups were unbalanced at the univariate analysis. To minimize this bias, a 1:1 propensity score-matching analysis (PSA) was used. Disease-free survival (DFS) curves were analyzed by the Kaplan-Maier method.ResultsThe PSA allowed pairing of 200 patients (100 for AR and 100 for PSR). In this study, 59 patients (62.8%) had recurrence after AR compared with 58 patients (63.7%) after PSR (p=0.891). The rates of local recurrence were respectively 15.3% and 15.5% (p=0.968). When microvascular invasion was considered, the median DFS was 10.7months for AR and 9.4months for PSR (p=0.607). In comparisons of AR and PSR, DFS did not differ significantly between subgroups with high histologic grading (p=0.520), multiple nodules (p=0.307), and Child-Pugh B (p=0.679).ConclusionExcision of the anatomic segment did not seem to reduce the rate of relapse or recurrence patterns significantly, even in high-risk subgroups.

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