期刊
ANNALS OF SURGICAL ONCOLOGY
卷 25, 期 12, 页码 3427-3435出版社
SPRINGER
DOI: 10.1245/s10434-018-6680-6
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AimTo identify factors associated with refusal of surgery in patients with early-stage pancreatic cancer and estimate the impact of this decision on survival.MethodsUsing the National Cancer Data Base, 26,358 patients were identified with potentially resectable tumors (pretreatment clinical stage I: T1 or T2 N0M0). Multivariate models were employed to identify factors predicting failure to undergo surgery and assess the impact on survival.ResultsOf early-stage patients who were recommended surgery, 7.8% (N=992) refused surgery for resectable early-stage pancreatic cancer. On multivariable analysis, patients were more likely to refuse surgery if they were older [odds ratio (OR)=1.18; 95% confidence interval (CI) 1.16-1.19], female (OR=1.52; 95% CI 1.33-1.73), African American (vs White, OR=1.79; 95% CI 1.37-2.34), on Medicare/Medicaid (vs private, OR=2.75; 95% CI 1.54-4.92) or had higher Charlson-Deyo score (2 vs 0, OR=1.33; 95% CI 1.03-1.72). Patients were also significantly more likely to refuse surgery if they were seen at a center that is not an academic/research program (OR 1.9; 95% CI 1.6-2.27). Patients who were recommended surgery but refused had significantly worse survival than those with stage I who received surgery [median survival 6.8 vs 24months, Cox hazard ratio (HR) 3.41; 95% CI 3.12-3.60].ConclusionsThe percentage of patients refusing surgery for operable early-stage pancreatic cancer has been decreasing in the last decade but remains a significant issue that affects survival. Disparities in refusal of surgery are independently associated with several variables including gender, race, and insurance. To mitigate national disparities in surgical care, future studies should focus on exploring potential reasons for refusal and developing communication interventions.
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