期刊
PHARMACOTHERAPY
卷 26, 期 4, 页码 515-521出版社
WILEY
DOI: 10.1592/phco.26.4.515
关键词
minocycline; stroke; neuroprotection
资金
- NINDS NIH HHS [R01 NS044216, R01 NS044216-02, R01 NS063965] Funding Source: Medline
Minocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat various gram-positive and gram-negative infections. Minocycline was recently shown to have neuroprotective properties in animal models of acute neurologic injury. As a neuroprotective agent, the drug appears more effective than other treatment options. In addition to its high penetration of the blood-brain barrier, minocycline is a safe compound commonly used to treat chronic infections. Its several mechanisms of action in neuroprotection-antinflammatory and antiapoptotic effects, and protease inhibition-make it a desirable candidate as therapy for acute neurologic injury, such as ischemic stroke. Minocycline is ready for clinical trials of acute neurologic injury.
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