Pt(II) vs Pd(II) polyamine complexes as new anticancer drugs:: A structure-activity study

Two homologous trinuclear polyamine chelates with either Pt(II) (la) or Pd(II) (lb) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50=32 mu M for lb vs 66 mu M for la).