期刊
SEMINARS IN ARTHRITIS AND RHEUMATISM
卷 35, 期 5, 页码 322-332出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semarthrit.2005.07.003
关键词
antiphospholipid syndrome; neoplasm; cancer; malignancy; antiphospholipid antibodies; anticardiolipin antibodies; lupus anticoagulant
类别
OBJECTIVE.- To describe the different types of malignancies associated with antiphospholipid antibodies (aPL). METHODS. We performed a computer-assisted (MEDLINE, National Library of Medicine, Bethesda, MID) search of the literature from 1966 to 2003 to identify all cases of malignancies having aPL. RESULTS: Cine hundred twenty patients were found. The mean age was 56 +/- 17 years (range 5 to 88). Sixty-two (52%) patients were men and 58 (48%) were women. A heterogeneous group of malignancies were found. Regarding hematological malignancies, 10 (8%) patients suffered from B-cell lymphoma, 8 (7%) from spleen lymphoma, 7 (6%) from chronic myeloid leukemia, and 6 (5%) from non-Hodgkin's lymphoma (NHU Regarding solid tumors, renal cell carcinoma was diagnosed in 7 (6%) patients, primary tumor with unknown origin in 7 (6%), lung adenocarcinoma in 6 (5%), breast carcinoma in 6 (5%), and melanoma in 6 (5%). The main aPL-related manifestations were thrombocytopenia (25%), cerebrovascular accidents (24%), deep vein thrombosis (19%), pulmonary embolism (15%), and heart valve lesions (9%). In 17 cases, catastrophic antiphospholipid syndrome was considered to be triggered by the malignancy. Seventy-one (63%) of 113 patients recovered or are still alive after cancer treatment. Twenty-three (35%) of 65 patients achieved aPL remission after proper treatment of the malignancy. CONCLUSIONS. It is important to bear in mind, especially in elderly patients, that thrombotic events associated with aPL can be the first manifestation of malignancy. At the same time, the presence of aPL in patients with malignancies has important implications in their treatment and prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据