期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 34, 期 2, 页码 50-53出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/00003677-200604000-00002
关键词
titin; passive force; differential splicing; posttranslational modification; muscle mechanics; mechanosensing
资金
- NHLBI NIH HHS [HL61497, HL62881] Funding Source: Medline
When muscles are stretched, the giant protein titin develops passive force. Titin's force performs important functions that include maintaining the structural integrity of the sarcomere and triggerng signal transduction pathways. We propose that the mechanical properties of titin can be tuned according to the mechanical demands placed on muscle, using mechanisms that include alternative splicing and posttranslational modifications.
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