期刊
BIOMATERIALS
卷 27, 期 11, 页码 2370-2379出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2005.11.015
关键词
biocompatibility; injectable; spinal cord injury; shear-thinning; thermally responsive material; intrathecal
Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques. A novel drug delivery system (DDS) is being developed in our laboratory that can provide localized release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, and biocompatible as an injectable intrathecal DDS. A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at the gelation point prior to injection. It is injectable due to its shear-thinning property, and its get strength increases with temperature. In vivo rat studies show that HAMC is biocompatible within the intrathecal space for 1 month, and may provide therapeutic benefit, in terms of behavior, as measured by the Basso, Beattie and Bresnahan (BBB) locomotor scale, and inflammation. These data suggest that HAMC is a promising gel for localized delivery of therapeutic agents to the injured spinal cord. (c) 2005 Elsevier Ltd. All rights reserved.
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