期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 16, 期 2, 页码 112-118出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2006.02.010
关键词
-
Proliferating cells need to synthesize large amounts of histones to rapidly package nascent DNA into nucleosomes. This is a challenging task for cells because changes in rates of DNA synthesis lead to an accumulation of excess histones, which interfere with many aspects of DNA metabolism. In addition, cells need to ensure that histone variants are incorporated at the correct chromosomal location. Recent discoveries have highlighted the importance of regulated histone proteolysis in preventing both the accumulation of excess histories and the mis-incorporation of histone variants at inappropriate loci.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据