期刊
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
卷 22, 期 2, 页码 100-104出版社
WILEY
DOI: 10.1111/j.1600-0781.2006.00199.x
关键词
cyadox; mouse; olaquindox; phototoxicity; skin
类别
Background: Cyadox is a veterinary drug mainly used as an effective antimicrobial promoter in animal husbandry. It was reported that the other quinoxaline-1,4-dioxide compounds had phototoxicity, but only few data are reported on phototoxicity of cyadox. This study was performed to evaluate the phototoxicity of cyadox on skin. Methods: Eighty mice were equally divided into eight groups. Five groups with ultraviolet A (UVA) irradiation for 2 h (21 J/cm(2)) were administered at doses of 0, 10, 50, 200 mg/kg cyadox and 50 mg/kg olaquindox, respectively, and others as controls without irradiation administered at doses of 0, 200 mg/kg cyadox and 50 mg/kg olaquindox, respectively. Drugs were administered by gavage once daily with a suspension in 0.8% carboxymethyl-cellulose for consecutive 4 days. After administration, a recovery period of 7 days was arranged. Histopathological examination of auricular skin was performed on days 5 and 12. Measurement of auricular thickness, gross pathology and erythema score were conducted once daily. Results: Cyadox groups (200, 50 and 10 mg/kg) with irradiation had erythema and oedema of auricular skin with dose-response relationship, which gradually convalesced after dosing and irradiation ceased. Severe erythema, oedema and necrosis of auricles were observed on olaquindox group with irradiation. Conclusion: The phototoxicity of cyadox was mild and reversible, which demonstrated a good safety profile of cyadox in terms of phototoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据