4.3 Article

Late-onset and rare far-advanced pulmonary involvement in patients with sarcoidosis in Taiwan

期刊

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
卷 105, 期 4, 页码 269-276

出版社

ELSEVIER TAIWAN
DOI: 10.1016/S0929-6646(09)60117-0

关键词

clinical manifestations; disease course; prognosis; sarcoidosis

向作者/读者索取更多资源

Background: Sarcoidosis is still considered a rare multisystem disorder in Taiwan, and data on the disease Course and outcome are limited. We analyzed the clinical manifestations, disease course and complications in Taiwanese patients with sarcoidosis. Methods: A retrospective cohort design was used. Fifty-six patients with sarcoidosis diagnosed between 1985 and 2004 were included. Their clinical features, laboratory findings at initial presentation, disease course, and complications were analyzed. Results: Forty-three patients (76.8%) were fernale. The mean age at symptom onset was 47 years. The most common clinical symptoms were pulmonary (82.1%), Cutaneous (23.2%), ophthalmic (19.6%), and articular (17.8%). Only two patients presented with Lofgren's syndrome. There was a seasonal variation in disease onset, with higher incidence in winter and early spring. No advanced pulmonary involvement was noted. Elevated levels of serum angiotensin converting enzyme (sACE) were found in 72.5% (29/40) of patients with active sarcoidosis, and significantly higher levels of sACE were found in patients with lung involvement (27.98 +/- 1.71 IU/L vs. 18.2 +/- 2.76 IU/L; p < 0.01). In 50% (20/40) of patients, sACE1- levels declined significantly in parallel with clinical remission (24.75 +/- 1.53 IU/L, vs. 16.33 +/- 1.21 IU/L; p < 0.05). Spontaneous complete remission was found in 20.7% of patients, whereas 39.6% of patients with multiple extrapulmonary involvement responded poorly to intensive corticosteroids plus various immunosuppressants. Conclusion: In this series, the mean age of disease onset was in middle age (mean, 47 years old), there was a low incidence of Lofgren's syndrome (3.6%), and no patients had advanced pulmonary syndrome. The results of this study also suggest that sACE might be a marker of pulmonary involvement that is also useful in monitoring disease activity. [J Formos Med Assoc 2006;105(4):269-2761

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据