期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 40, 期 7, 页码 1152-1160出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2005.11.003
关键词
chelator; chemoprevention; curcumin; iron; ferritin; glutathione S-transferase; free radicals
资金
- NIDDK NIH HHS [K01 DK065876, R37 DK 42412, KO1 DK065876] Funding Source: Medline
- NIEHS NIH HHS [R03ES011516] Funding Source: Medline
Curcumin is among the more successful chemopreventive compounds investigated in recent years, and is currently in human trials to prevent cancer. The mechanism of action of curcumin is complex and likely multifactorial. We have made the unexpected observation that curcumin strikingly modulates proteins of iron metabolism in cells and in tissues, suggesting that curcumin has properties of an iron chelator. Curcumin increased mRNA levels of ferritin and GST alpha in cultured liver cells. Unexpectedly, however, although levels of GST alpha protein increased in parallel with mRNA levels in response to curcumin, levels of ferritin protein declined. Since iron chelators repress ferritin translation, we considered that curcumin may act as an iron chelator. To test this hypothesis, we measured the effect of curcumin on transferrin receptor 1, a protein stabilized under conditions of iron limitation, as well as the ability of curcumin to activate iron regulatory proteins (IRPs). Both transferrin receptor I and activated IRP, indicators of iron depletion, increased in response to curcumin. Consistent with the hypothesis that curcumin acts as an iron chelator, mice that were fed diets supplemented with curcumin exhibited a decline in levels of ferritin protein in the liver. These results suggest that iron chelation may be an additional mode of action of curcumin. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据