期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 4, 页码 612-615出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0504661
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资金
- NIGMS NIH HHS [R01 GM060600-02, R01 GM060600-03, R01 GM060600-06, R01 GM060600-04, R01 GM060600-07, R01 GM060600-01, R01 GM060600, R01 GM060600-05, GM 60600] Funding Source: Medline
Four new altenuene derivatives called dihydroaltenuenes A (1) and B (2) and dehydroaltenuenes A (3) and B (4), along with five known compounds, including isoaltenuene (5), altenuene (6), and 5'-epialtenuene (7), were isolated from cultures of an unidentified freshwater aquatic fungal species in the family Tubeufiaceae. The structures of 1-4 were determined by analysis of NMR and MS data. The relative stereochemistry was determined on the basis of H-1 NMR J-values and NOE data, while the absolute configuration of a representative member of the group (5) was assigned by CD spectral analysis of its bis-N, N-dimethylaminobenzoate derivative. Compounds 1, 3, 4, 5, and 6 showed antibiotic activity against Gram-positive bacteria.
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