期刊
TRENDS IN IMMUNOLOGY
卷 27, 期 4, 页码 169-175出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2006.02.004
关键词
-
类别
The classic dichotomy model of hematopoiesis postulates that the first step of differentiation beyond the multipotent hematopoietic stem cell generates the common myelo-erythroid progenitors and common lymphoid progenitors (CLPs). Previous studies in fetal mice showed, however, that myeloid potential persists in the T- and B-cell branches even after these lineages have diverged, indicating that the simple dichotomy model is invalid, at least for fetal hematopoiesis. Nevertheless, CLPs have persisted in models of adult hematopoiesis; results from several groups support the presence of CLPs in bone marrow. Recent evidence challenges the dichotomy model in the adult, and it is proposed here that the alternative myeloid-based model is applicable to both fetal and adult hematopoiesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据